Immunocompromised? Need protection against Covid-19?

You would think that I would have lots of protection against Covid-19. I have not only had the vaccine, but two boosters. Still my antibodies have been 366 at the highest with the range being zero to a little over two thousand.

I decided to seek other options to protect myself. I found out about Evusheld from one of my cancer groups. Evusheld is a combination of two monoclonal antibodies (tixagevimab and cilgavimab) injected one in each hip/buttocks to protect the immunocompromised patient from Covid-19. The medications are lab-made proteins that act like antibodies to fight infections.

Not every person is qualified to get the injections. First of all, you need to have a medical condition or have not developed a strong enough response to the Covid-19 vaccine. You have to be at least 12 years old and weigh at least 88 pounds. You cannot be currently infected with SARS-CoV-2 and have not had close contact with an infected person.

The medicine needs to be prescribed by your physician. It is not an FDA-approved medicine in the United Stated; however, the FDA has issued an Emergency Use Authorization (EUA).

The entire process lasts 90 minutes. After the two injections, the remainder of the time is spent observing your response. I did not have any issues with the injections, nor did I have any side effects.

The injections do not increase your antibodies. What happens is that your cells are neutralized with a “shield” so that the virus cannot attach itself.

PLEASE READ THIS UPDATE:

The information I posted came from the nurse who injected the Evusheld in me.

Beth's comments are worth reading:

Beth has left a new comment on your post "Immunocompromised? Need protection against Covid-19?":

I always enjoy your posts, but think that in your most resent post that you have misrepresented Evusheld. The monoclonals that comprise Evusheld are anti-spike antibodies, binding only to the spike protein of the virus. Your cells are not neutralized with a shield so that the virus cannot attach. Evusheld antibodies do not bind to your cells. That would be the case with anti-ACE2 antibodies, which would coat the cell prohibiting spike attachment, but that is not how Evusheld works. Tixagevimab and cilgavimab bind to the spike, preventing the virus from binding to the ACE2 protein on the cell surface.

Also, I do not think that there is any weight limitation for adults. According to my reading of the Evusheld Fact Sheet, the 88 lb cutoff applies to adolescents. https://www.fda.gov/media/154701/download

One other comment that is a bit misleading is that the range of antibody production post-vaccination is “zero to a little over two thousand”. The >2500 is simply the cut-off for what is reported by Labcorp. In healthy individuals the actual antibody titer is frequently 10+ times higher than the reported cut-off level.